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Notably, PolyQ diseases are classified as late-onset disorders, with symptoms typically manifesting in adulthood and progressively worsening over a period of 10 to 30 years (Paulson et al., 2000)

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Remethylation Methionine synthase uses methylcobalamin and 5-methyl-THF to recycle homocysteine to methionine

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Phosphorylated ATF1 further improves macrophage adaptation to intraplaque hemorrhage, thus maintaining the homeostasis under dural iron-lipid stress (178)

To explore the role of glutathione in pancreatic fibrosis and -cell failure induced by hyperglycaemia, we established a rat model of pancreatic fibrosis and -cell failure