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The key role of GSH as an antioxidant is demonstrated by many studies showing that experimental depletion of GSH levels which can be achieved with various chemicals the most used of which is buthionine sulfoximine (BSO) an inhibitor of GSH synthesis has a worsening effect in many disease models

So, what are the key differences between IV push vs bolus

Keep tubing, syringes, catheters, bags, and generator output away from the face

But measurably

A redox shift is a change in the bioenergetic supply of electrons, leading to changes in the intracellular ratio of NAD + /NADH as redox currency, oxidized glutathione over GSH (GSSG/GSH) as redox buffer, and plasma cystine/cysteine (cySS/cys) as systemic buffer

Depletion of a discrete nuclear glutathione pool by oxidative stress, but not by buthionine sulfoximine