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High levels of PUFAs are located in the outer photoreceptor segment and produce substantial amounts of intracellular ROS, making the retina especially susceptible to damage from oxidative stress (166) ( Figure 3 )

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Authors showed upregulation of transcripts related to inflammation, wounding and defence responses, complement and coagulation and cytokinecytokine receptor interaction pathways (24)

Together, these findings show that ESA induces ferroptosis as a single agent and distinguishes ESA from arachidonic and adrenic fatty acids, which sensitize cells to GPX4 inhibition but do not induce ferroptosis 13,17

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