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doi: 10.1097/IMNA-D-22-00016 231 ZhongZ.ZhangY.WeiY.LiX.RenL.LiY.et al

By summarizing articles related to fatty acid metabolism and RF, we conclude that the dysregulation of the PPAR/PGC-1 core axis initiated by miRNAs such as miR-21, miR-150, miR-9-5p, and miR-495, along with the drive of CPT, a key enzyme in fatty acid oxidation, mediates lipotoxic cascades

and therefore, these strains are the main ones responsible for MLF (Tracey and Britz, 1987

Crucially, we aim to delineate a forward-looking path towards precision medicine within this vital field, particularly by leveraging insights from individual patient oxidative stress profiles, robust biomarker development, and advanced technological integration to tailor treatment strategies and ultimately improve patient prognosis