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48 This biomarker has, therefore, been proposed for the early identification of patients with pre-eclampsia at risk of developing a severe HELLP syndrome, although its clinical utility is questionable due to increased D-dimer during physiological pregnancy (see above)

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Patients with gastric cancer with elevated CEA and NNMT had significantly poorer prognosis than those with only one positive marker, suggesting that combining NNMT with other biomarkers improves clinical diagnostic accuracy (43)

It should be noted, however, that ALDH1A1, but not CYP2E1, is a downstream target of NRF2, which was found to be activated in untreated GCLM KO mouse liver

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