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The conjugation reactions transfer functional groups (e.g., glucuronic acid, sulfate, methyl, acetyl) from endogenous molecules to the drug or metabolite, resulting in the formation of highly polar and water-soluble conjugates

Ciotta, L., Stracquadanio, M., Pagano, I., Carbonaro, A., Palumbo, M., & Gulino, F

Astrocytes can use them to temporarily sequester excess extracellular K + and release it as a buffer when K + levels decline

Cell Host and Microbe 16(3):276289

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That rationale must be backed by non-clinical data confirming the compound behaves as expected and by a thorough safety and toxicology program that identifies potential risks and establishes a safe starting dose for the first human administration and the maximum human exposure that should not be surpassed