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Description

Tocopherol is a fat-soluble antioxidant known as Vitamin E

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In preclinical models, simultaneous deficiency in NAD+ and GSH is associated with accelerated mitochondrial dysfunction

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10.1038/srep39374 Sci

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The key pathological hallmarks of AD include amyloid-beta (A) plaque accumulation, neurofibrillary tangles of hyperphosphorylated tau, chronic neuroinflammation, oxidative stress, and mitochondrial dysfunction (Lv et al., 2020)

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Figure 5 Deferoxamine chelates iron and inhibits ACSL4, while rosmarinic acid activates Nrf2 by disrupting its Keap1 interaction

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