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Lifestyle factors matter: sleep, nutrition, and stress alter hormone responsiveness and can make a stack less effective if not addressed

Cagrilintide may affect metabolic signaling through amylin receptor activation, gastric emptying models, glucagon-related pathways, and communication between pancreatic, gut, and brain-based systems

Lifestyle modifications and multidisciplinary care strategies can enhance patient outcomes

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To prevent IRs, both isatuximab and daratumumab require systemic premedication with corticosteroids, acetaminophen, and antihistamines [13, 15]