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38 Iron overload Although iron is a helpful component of the human body and the major micronutrient in the human diet, involved in crucial cellular functions and metabolic processes, excessive iron increases the production of ROS, leading to cell dysfunction or death, tissue damage, and organ disease

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We observed increased DNA-damage foci (H2AX) in CCNE1 -overexpressing cells, similar to the positive control cisplatin (Extended Data Fig

A follow-up reported treated cells divided 44 times versus 34 in controls

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Acknowledgments This study was supported by the Jiangsu Provincial Medical Youth Talent (grant number QNRC2016653)