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Among them, bone marrow-derived MSCs (BM-MSCs) were the first type of isolated MSCs and the most commonly used cell type for lung diseases (Antunes et al., 2014b), which may have a better immunomodulatory ability than MSCs from other sources

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Direct effect of UA on neutrophils MSU crystals induce neutrophil migration (47), playing a critical role in acute inflammatory responses, including infections and sterile injuries characterized by crystal deposition

Future research should focus on three directions: (1) Elucidating the specific molecular mechanisms of interactions between endothelial cells and other renal cells (mesangial cells, podocytes and pericytes), including the identification of key signaling molecules and their downstream effectors