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ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA

An increasing body of evidence suggests that disturbances in the pulmonary mechanical microenvironment, a complex interplay of extracellular matrix (ECM) stiffness, alveolar surface tension, cellular forces, and cell-matrix interactions, play a crucial role in the pathogenesis and progression of these diseases ( Owing to their unique size and highly tunable physicochemical properties, nanomaterials present unparalleled opportunities to finely adjust the pathological microenvironment within the lungs ( Here, we explore how nanomaterials can address dysregulation in the lungs mechanical microenvironment by modulating ECM properties, normalizing alveolar surface tension, and influencing mechanotransduction pathways in pertinent lung cells

doi: 10.1160/TH12-04-0275 [DOI] [PubMed] [Google Scholar] 44

0:00 - Introductions: Reconnecting with Katie Emerson at Expo West 2025 The episode opens with Mike and Ben welcoming Katie Emerson back to the podcast after roughly 18 months

Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females

The rationale for stacking is that different peptides operate through different mechanisms and do not typically compete or interfere with each other when used at standard doses