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Pasculli RM, Kenyon CD, Berrigan WA, Mautner K, Hammond K, Jayaram P

Once considered to be a disease of advanced old age, today the condition is affecting much younger patients, often in their late middle age

YBX1 regulates satellite II RNA loading into small extracellular vesicles and promotes the senescent phenotype

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Additionally, androgen excess upregulates miR-223, which suppresses glucose transporter type 4 (GLUT4) expression and worsens insulin resistance (55)