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117 Glucose starvation also induces the phosphorylation of the leucine sensor LARS1 by ULK1 at residues important for Leu binding, thereby reducing the affinity of LARS1 for leucine

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This matters because you can't assess whether a dose is clinically relevant if you don't know what's in there

166 This could be taken as a warning to monitor the caloric and glycemic load of the diet to avoid overnutrition of patients that would resemble the feeding of control animals in the preclinical DR studies

For this purpose, metabolomics stands out as a suitable approach to get deeper insights into disease pathophysiology, as metabolites represent accurate phenotypic indicators of the close interplay between host metabolism and exogenous factors [3]

Zhao H, Ye L, Wang Y, Zhou X, Yang J, Wang J, Cao K,Zou Z