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However, it was shown that GSH depletion induces ferroptosis in some cell types but not others 23

Moreover, NEDD4 knockdown in HK-2 cells was adequate to inhibit the ubiquitination of PPAR (Fig

53 , D1670D1676 (2025)

In addition to pyruvate-derived acetyl-CoA, -KG-derived metabolites (e.g., succinate and fumarate) generated via glutaminolysis are considered oncometabolites contributing to tumorigenesis 23