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Imaging approaches such as DCE-MRI and PET not only demonstrate region-specific alterations but also suggest that these alterations differ from those observed in other neurological conditions, pointing toward possible disease-specific mechanisms

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GpoA significantly enhances the bacteriums ability to withstand hostile environments generated by the host immune response, and it also affects in vivo survival, as the gpoA mutant exhibited reduced survival compared to the wild-type strain in various organs of infected mice

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Therefore, more efforts need to be made to focus on these issues in future studies on VNS