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Description

As estrogen drops, fat shifts from the hips and thighs to the abdomen, and visceral adiposity rises even when total body weight is stable

Early signs can include increased thirst, more frequent urination, unusual fatigue (especially after meals), and cravings for carbohydrates

In addition, urinary IGF-1 concentrations are associated with kidney size and microalbuminuria in these patients [201]

This is critical context for cycle length discussions, because chronic stimulation of ANY receptor system creates the potential for desensitization and antibody formation over time

Specifically, those are the growth hormone secretagogue receptors type 1a (GHS-R1a), which also respond to the hormone ghrelin

Moreover, there is an indication that Ipamorelin might have elevated serum leptin levels, a hormone that is thought to play a role in energy and appetite regulation