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This patient was lost to follow-up, and we are unaware of his most recent clinical status

Last, to determine the impact of AKT-dependent regulation of glycolysis on NADPH production we used Fluorescence Lifetime Imaging Microscopy (FLIM) technology to compare NADPH/NADH ratio in AKT-E17K and AKT-WT TrC1 in untreated controls and upon irradiation with 5 Gy with and without additional treatment with the AKT-inhibitor MK2206 ( Figure S3E, F )

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These in vivo measures are arguably more accurate and provide additional information to help determine if GSH may be considered a therapeutic target

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received research grants from AbbVie, Sanofi/Genzyme, Combe, Gliknik