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(1) ROS directly attacks the mitochondria of chondrocytes, causing leakage of the electron transport chain (ETC) and further generating superoxide anion (O ), which forms a vicious cycle, inducing collapse of mitochondrial membrane potential and ATP synthesis disorder

Effect of glutathione depletion on antioxidant enzymes in the epididymis, seminal vesicles, and liver and on spermatozoa motility in the aging brown Norway rat. Biology of reproduction, 71(3), 1002-1008

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10.1016/j.abb.2008.06.004 Arch Biochem Biophys

For samples run on the ZIC-pHILIC column, the MS scan range (m/z) was set to 60900