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4.1 Re-evaluating therapeutic approaches in AD For years, the amyloid cascade hypothesis has been the dominant framework guiding AD research

doi: 10.1093/plphys/kiac113 74 ParkJ.LimC

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Nitric oxide inhibition of cAMP synthesis in parotid acini: regulation of type 5/6 adenylyl cyclase

Second, central to the "iron-dependent" nature of ferroptosis, ferrous ions (Fe 2 ) in the labile iron pool are the key catalysts for the Fenton reaction, which generates highly reactive hydroxyl radicals

Less immune-cell infiltration into the postischemic area suggested either that Fer-1 directly inhibits leukocyte transmigration or that the local proinflammatory microenvironment was less chemoattractive, presumably by less damage-associated molecular pattern (DAMP) release due to less ferroptotic cell death