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PMID: 16030155

However, in individuals with preexisting neoplastic conditions, excessive intake, particularly of synthetic folic acid, may increase cancer risk, although this relationship remains to be fully elucidated (61)

Taken together, these findings indicate a time-dependent interaction between corticosteroids and stem cell-based therapies: short-term local corticosteroid exposure may synergize with MSC-mediated immunoregulation, whereas prolonged systemic corticosteroid use may impair MSC licensing by suppressing critical inflammatory signals such as IFN-