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Histone-derived peptides Histone proteins are among the primary targets of autoantibodies in lupus

Some patients benefit from weekly injections at first, while others maintain results with monthly treatments

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The peptide's activation of ERK1/2 and downstream transcription factors including Egr-1 drives expression of collagen synthesis genes while its enhancement of cellular migration ensures efficient fibroblast recruitment to sites requiring matrix deposition, creating optimal conditions for rapid yet organized tissue reconstruction

Kanchandani R, Howe J

These include fatigue, irritability, poor concentration, brittle nails, scratches, depapillation of the tongue, and hair loss