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Finally, the joint application of AS-IV with these compounds significantly reduces caspase-12 expression in brain tissue after I/R, inhibits phosphorylation of JNK1/2 proteins, and increases GRP78 protein expression

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Additionally, the nuclear transcription factor (Foxo1) is phosphorylated upon activation of phosphoinositide- 3-kinaseprotein kinase B/Akt (PI3 K-PKB/Akt), which in turn deactivates molecules to restrict the activity of proapoptotic pathways [66]

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This suggests that under T2 stressed conditions, increases in SLC7A11 activity help maintain intracellular redox balance (Figure 3G)