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Thus, we determined ER-stress response genes Xbp1 and the ER chaperone heat shock 70 kDa protein 5 (HSPA5, previously known as immunoglobulin heavy chain binding protein [BIP]), inflammation-responsive genes IL6 and IL1, and hypoxia-responsive genes hypoxia-inducible transcription factor 1 (HIF1) and GAPDH

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Two enzymes are involved in glutathione synthesis

Overall, treatment targeting juvenile worms resulted in smaller decreases in worm and egg burdens, which could be associated with higher ABC and MDR transporter activity in juvenile worms than adult worms 55

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