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Animal data suggest subcutaneous routes required substantially higher doses than intravenous in rabbits, 1 mg/kg subcutaneous versus 25 mcg/kg IV, a 40-fold difference

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2 Method This review aims to summarize the mechanism of ferroptosis in the pathogenesis of atherosclerotic comorbid depression and to highlight the research progress on the use of Chinese medicine in treating this condition by targeting ferroptosis

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Specifically, research indicates that fucoidan can protect against cellular senescence by regulating key proteins involved in the cell cycle and apoptosis, particularly in mesenchymal stem cells exposed to stressors like p-cresol 191 (Fig