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Based on our research, once there is lymph node metastasis, lung cancers with a GGO component have an equally bad prognosis to their solid counterparts. This and other work raise concerns about limiting LDCT screening for lung cancer to older, long-term smokers, as is currently done in many Western countries based on the results of the National Lung Screening Trial and the NELSON trial

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J Cell Biochem (2006) 97:13708.10.1002/jcb.20741 49 DavisRRizwaniWBanerjeeSKovacsMHauraECoppolaDet alNicotine promotes tumor growth and metastasis in mouse models of lung cancer