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Across the 1980s and 1990s, GHK-Cu was studied extensively in wound healing applications, where it consistently demonstrated the ability to accelerate skin repair, stimulate collagen and glycosaminoglycan synthesis, and reduce inflammation at the site of injury

While early, smaller trials showed promise by reducing infarct size (Piot et al., 2008), the larger CIRCUS trial subsequently failed to demonstrate improved clinical outcomes (Cung et al., 2015)

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Building on this finding, our group has continuously optimized zunyimycin extraction methods and further investigated its mechanisms of action as an AD interventions

Efficacy of invasive laser acupuncture in treating chronic non-specific low back pain: A randomised controlled trial

However, retrospective studies have shown that CU is uncommon in elderly patients, and elderly CU patients have a shorter course of disease than younger CU patients