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Ricci F, et al

Moreover, E GSH [IMS] was not affected in a glr1 strain, while E GSH [cytosol] became significantly more oxidizing than in wildtype (wt) cells

The process of electron transfer through the reversible transformation of active site sulfhydryl-disulfide (SH/-S-S-) is the core mechanism of the Trx system (21)

However, natural glutathione levels can decline due to aging, stress, poor diet, illness, pollution, and lifestyle factors, which is why dietary support and supplementation have gained attention