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203 Glutamatergic excitotoxicity Glutamate is the main excitatory neurotransmitter of glutamatergic neurotransmission in the CNS

Intriguingly, treating cells with high concentrations of extracellular glutamate competitively hinders cystine uptake via the xCT system, resulting in cystine/GSH exhaustion and subsequent accumulation of lipid hydroperoxides [12, 29]

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