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197 Additionally, mRNA-3704 and mRNA-3705 encode MUT, which is designed to treat methylmalonic acidemia and is currently under investigation

DC, dendritic cell

Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor coactivator 1

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study ( In addition, CSD, a hallmark of migraine pathogenesis, can cause oxidative stress ( On a molecular basis, the TRPA1 (Transient receptor potential ankyrin subtype 1) ion channels in nociceptors allow the release of calcitonin gene-related peptide (CGRP) from dural afferents upon activation, mediating neurogenic inflammation, and migraine behavioral picture in animal models ( Neuroinflammation Neurogenic inflammation describes the phenomenon of arteriolar vasodilation, plasma protein extravasation, and degranulation of mast cells, caused by the release of potent vasoactive neuropeptides (mainly CGRP, substance P, and neurokinin A) from activated peripheral nociceptive nerve terminals

Antalis TM, Shea-Donohue T, Vogel SN, Sears C, Fasano A (2007) Mechanisms of disease: protease functions in intestinal mucosal pathobiology