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Clinically, the occasional but limited use of a drug with the potential for abuse or dependence is distinct from the emergence of addiction

For example, CTR1 promotes angiogenesis by regulating the entry of copper into endothelial cells, activating a multitude of pro-angiogenic and inflammatory factors

Tau also prevents a high-fat diet from elevating the LDL and VLDL cholesterol levels

Neuron 78 , 8193 (2013)

In addition, shifting away from mandatory surgical confirmation toward a clinically driven diagnostic model supported by imaging can accelerate diagnosis and initiation of treatment

Food and Drug Administration (FDA), [note 9] amphetamine is contraindicated in people with a history of drug abuse, [note 10] cardiovascular disease, severe agitation, or severe anxiety