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doi: 10.1371/journal.pone.0155901 87 Recuero S daCVianaNIReisSTMendesKTTalibLLGattazWFet al

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Repeated and frequent episodes of hyperammonaemia (alongside metabolic decompensations) can result in impaired growth and intellectual disability, the severity of which increase with longer duration of hyperammonaemia

This compound demonstrates remarkably potent genotoxic effects in colonic epithelial cells, operating through mechanisms distinct from classic NOCs: it generates reactive oxygen species, lipid peroxidation products, and DNA-reactive aldehydes at concentrations five- to sixfold lower than required for equitoxic effects from non-nitrosylated heme (16)

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It is intended only for properly supervised in vitro experimentation or authorized non-human preclinical research conducted by trained and qualified personnel