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Moreover, N-nitroso-N-methylbenzylamine (an environmental carcinogen) has caused a greater increase in oxidative DNA damage (8-hydroxydeoxyguanosine) and oesophageal tumourigenesis in riboflavin-deficient rats compared with the sufficient ones (Reference Pan, Chen and He47)

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Second, the direct crosstalk between systemic iron homeostasis (e.g., the hepcidinferroportin axis) and intracellular ferroptosis signaling is poorly characterized

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