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Recently, using the genetically encoded fluorescence resonance energy transfer (FRET) lactate sensor Laconic, a lactate gradient from astrocytes to neurons was demonstrated in vivo (Mchler et al., + /K + -ATPase pump coupled to glutamate transport (consuming one ATP) and the glutamine synthetase (consuming another ATP) for the maintenance of the glutamate-glutamine cycle (Pellerin and Magistretti, 1994)

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Phosphoserine phosphatase promotes lung cancer progression through the dephosphorylation of IRS-1 and a noncanonical L-serine-independent pathway

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