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The inflammation triggers the overproduction of melanin, a skin pigment that gets deposited in the skin, causing dark patches to remain even after the injury or inflammation has healed

Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China

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It states that when pain signals constantly stimulate the central nervous system, it undergoes maladaptive changes like increased neuronal activity, activation of microglia and astrocytes, and the production of cytokines that promote inflammation [13]