chac1 er stress glutathione degradation TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione-degrading enzyme This figure illustrates the interactions

This figure illustrates the interactions and regulatory mechanisms Download Scientific Diagram Frontiers CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers Endoplasmic reticulum stress: molecular mechanism and therapeutic targets Signal Transduction and Targeted Therapy Long noncoding RNA GDIL acts as a scaffold for CHAC1 and XRN2 to promote platinum resistance of colorectal cancer through inhibition of glutathione degradation Cell Death & Disease ChaC1 based drug screenings identify a synergistic lethal effect of auranofin and proteasome inhibitors in hepatocellular carcinoma cells Cell Death Discovery Glutathione (GSH) depletion by ChaC1 results in a more oxidizing Download Scientific Diagram

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