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The production of IGF-1 is stimulated by growth hormone (GH) and can be retarded by undernutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signaling pathway post GH receptor including SHP2 and STAT5B

Food Res Int 51:123131 Pascual O, Vignault A, Gombau J, Navarro M, Gmez-Alonso S, Garca-Romero E, Canals JM, Hermosn-Guterrez I, Teissedre PL, Zamora F (2017) Oxygen consumption rates by different oenological tannins in a model wine solution

there are studies that reported reduced cardiovascular damage by recombinant administration of SOD3 [80, 81]

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