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We also investigated differences in the inter-analyte relationships between ME/CFS and HC, by building an analyte-analyte correlation network at each time point using all analytes significantly associated with ME/CFS

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To confirm that the effects we observed were through on-target activity, we further demonstrated that GCLM knockdown with siRNA conferred hypersensitivity to EN25-mediated cell viability impairments compared to non-targeting siControl A2780 cells (Fig

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The strong correlation among PARP1 overactivation, limiting NAD + pools and inhibition of SIRT1 activity is observed in a broad spectrum of human diseases, including xeroderma pigmentosum group A, progeroid diseases, ataxia telangiectasia and Cockayne syndrome

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