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Adverse Reactions Occurring at an Incidence of 5% or More and At Least Twice Placebo Among VYVANSE Treated Patients with BED in Clinical Trials The most common adverse reactions (incidence 5% and at a rate at least twice placebo) reported in adults were dry mouth, insomnia, decreased appetite, increased heart rate, constipation, feeling jittery, and anxiety

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In that case, try a supplement containing wheat dextrin (Benefiber) or methylcellulose (Citrucel)

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Like the PCSK9 trial, this trial is testing a range of doses for safety and efficacy