glutathione synthetase deficiency prevalence dysregulation and the etiology and progression of human diseases Frontiers | Glutathione and mitochondria

A compound can be widely discussed and still rest almost entirely on cell-culture and animal data, with little or no controlled human evidence

Additionally, a significant association was observed between NAFLD and calcified coronary plaques (RR: 1.55, 95% CI: 1.05, 2.27)

Chebolu, S., Wang, Y., Ray, A

This shift is consistent with the SECs are in a state of cellular senescence or quiescence with an increased focus on maintaining existing protein function through post-translational modification (dephosphorylation) and tightly controlling gene expression (mRNA regulation), which is consistent with the characteristic dysfunction and loss of regenerative capacity seen in aged endothelium

Additionally, the glutathione supplement should have undergone rigorous testing for safety, efficacy, and purity

[1] What the best bioavailability trial actually showed The most rigorous test of this question was a six-month, randomized, double-blind, placebo-controlled trial of oral glutathione at 250 or 1000 mg/day in 54 non-smoking adults