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Regulatory effect of iron regulatory protein-2 on iron metabolism in lung cancer

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Although the mitochondrial and lysosomal membranes form specific contact sites mediated by tethering proteins, it is important to emphasize that they do not fuse, but instead maintain their distinct structures and characteristics, which are crucial for their roles as major platforms in regulating various physiological processes, such as the mitochondrial network, lysosomal dynamics, calcium homeostasis, and lipid metabolism, all of which have been implicated in Parkinsons disease (PD), CharcotMarie-Tooth (CMT) disease, and lysosomal storage diseases (LSDs) (Cantarero et al., 2021

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