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These subunit types are differentially expressed in the nucleus accumbens, dorsal striatum, prefrontal cortex, and hippocampus (Reimers et al., 2011)

The importance of these pathways in yielding pyruvate in the absence of pyruvate kinase is further supported by many reports showing that inhibition of this enzyme does not lead to a proportional decrease in pyruvate/lactate formation, reviewed in ref

A non-alcoholic Japanese patient with Wernicke's encephalopathy and Marchiafav-Bignami disease

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doi: 10.1111/bjd.12536