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In modern clinical and animal studies, they have been found to be very effective in the treatment of PCOS and also slightly improve IR by alleviating inflammation, remodeling intestinal homeostasis, or by regulating the PI3K/Akt signaling pathway, among other mechanisms (311314)

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Smac promotes caspase-3 and -7 activation by neutralizing inhibitor of apoptosis proteins (IAPs), including cIAP-1, cIAP-2, and XIAP [53]

Body composition outcomes were studied by a handful of mouse models utilizing cell-specific promoters driving ARKO within SCs [191, 192, 203], myoblasts [183, 204], myocytes [187, 205,206,207,208], myofibers [183, 204, 209], neurons [192, 210, 211], osteoblasts [212,213,214], osteoclasts [182], and adipose [215, 216]