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A Randomized Crossover Intervention Study on the Effect a Standardized Mat Extract (Ilex paraguariensis A

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Mechanistically the peptide is hypothesised to act as a 'gene-regulatory short peptide': because of its small size it is proposed to reach the nucleus intact and to bind DNA at specific motifs

HF is indeed associated with profound perturbations of mitochondrial life cycle partly due to down-regulation of PGC-1 and its downstream target genes, which control the renewal of the mitochondrial pool of cardiomyocytes [132], thereby leading to the accumulation of mitochondrial defects reported in the failing myocardium

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