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Long-term human safety has not been established through large clinical trials

H., Kim, J

Hippocampal neurogenesis mainly occurs in the subgranular zone (SGZ) of the dentate gyrus, where newborn neurons are continuously generated and integrated into existing circuits, thereby contributing to hippocampal plasticity, learning, and memory

Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo

Drug/Laboratory Test Interactions Triamterene and quinidine have similar fluorescence spectra

18 Decisions regarding these medications should factor in other comorbid conditions that have FDA indications or evidence of potential benefits in AUD that may guide the choice of treatment, as detailed in Figure 1 and Tables 2 and 3