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Collectively, NAD + exerts its effects not through traditional receptor binding but through its indispensable role as a co-substrate and regulator of these enzymatic systems, which sense and respond to fluctuations in NAD + levels to coordinate cellular metabolism, survival, DNA repair, signaling, and cell fate decisions 1-4

Kireyeva, Y.P

It is also possible that APOE4s effect in enhancing alpha-synuclein pathology is associated with the brain changes examined, considering it a major protein pathology in PD and DLB, as well as its role in neurodegeneration independent of AD-like changes (Davis et al., 2020

Glutamine also possesses anti-inflammatory activity via deactivating cytosolic phospholipase A2 (cPLA2)

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2018, doi:10.3390/ijms19071987