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Most Common Side Effects Dry mouth Insomnia or disrupted sleep Increased heart rate or blood pressure Mild nausea (typically dose-related and temporary) Restlessness or mild anxiety in sensitive individuals Adverse events were mostly mild to moderate and occurred during early weeks of treatment

Funding This work was supported by the Natural Science Foundation Council of China (81922081and 81700780)

For example, after a 12-week cycle, a 4- to 6-week break is often sufficient for biomarkers to normalize

Vitamin B12 is a water-soluble vitamin, meaning the body does not store excess amounts in fat tissues

Stop smoking two weeks before the procedure so as not to negatively affect the results

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