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As far back as the 1970s, there were case reports in the literature of B12 deficiency associated with metformin use, with several observational studies reporting the same, but very little in the way of high-quality, well-powered, prospective studies

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RESEARCH CONTEXT NOTICE: This article discusses compounds available for laboratory and research use only

Fatigue is also a symptom of high blood sugar, as people taking the type 2 diabetes drug may experience, the Mayo Clinic says

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