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The authors speculated that variations in participant characteristics, such as age or gender, might account for discrepancies between their findings and those of previous studies

It takes approximately 4 to 5 weeks for the drug to reach a steady level in the body, and total effects may not be apparent for at least two months after treatment begins

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In this context, Colasanti and coworkers have identified to homocysteinylated A1AT (Hcy-A1AT) in 54.4% of seropositive RA, but not in seronegative cases, indicating their potential relevance in the disease (94)