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Targeted manipulation of lipid DAMP signaling, macrophage polarization, or T-cell susceptibility to oxidized lipids may unlock the potential of ferroptosis-inducing agents not just as cytotoxic therapies, but as immune modulators capable of tipping the TME toward durable anti-tumor immunity

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GHK-Cu is an endogenous occurring copper-binding tripeptide composed of glycine (G), histidine (H), and lysine (K)