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Chrysin selectively downregulates MMP-10, demonstrating potent anti-metastatic effects in triple-negative breast cancer (TNBC) models (Monsef-Esfahani et al., 2014) Nepitrin, even at low concentrations, directly inhibits the enzymatic activity of MMP-2 and MMP-9, thereby attenuating proteolytic ECM remodeling (Yao et al., 2019), while luteolin suppresses MMP-2/9 expression to impair migration and invasion of cells of colorectal cancer and breast cancer (Li et al., 2015)

Isoquercitrin also promotes immunogenic cell death (ICD) in human gastric cancer cells through ER stress activation ( Sustained ER stress upregulates the C/EBP homologous protein (CHOP), a predominant pro-apoptotic transcription factor in ER, triggering downstream cascade responses (Kim et al., 2018)

For each child, age, gender, height, body weight, and liver function indicators, i.e., total protein (TP), albumin (ALB), alanine transaminase (ALT), aspartate transaminase (AST), glutamyltransferase (GGT), alkaline phosphatase (ALP), and total bilirubin (TBIL), were recorded

Reduction of lactate

Each daily serving provides a full 2 grams to help your body transport fat into cells where it can be used for energy, while also supporting reduced muscle soreness and faster recovery after training

For example, carnitine-modified drugs can effectively target OCTN2 transporters to improve drug bioavailability [182, 183]